Wednesday, August 22, 2018

Instrumentation: Measurements, Signals and Data


A signal may be defined as the output of a transducer that is responding to the chemical system of interest. The signal may be separated into two parts, one caused by the analyte(s) and the other caused by other components of the sample matrix and the instrumentation used in the measurement. This latter part of the signal is known as noise. 
Although the ability to separate significant data-containing signals from meaningless noise has constantly been a desirable property of any instrument, it has become imperative with the demand for progressively more sensitive measurements. The amount of noise present in an instrument system determines the smallest concentration of analyte that can be accurately measured and also fixes the precision of measurement at larger concentrations.
 Noise reduction (or signal enhancement) is a primary consideration in obtaining useful data from measurements that involve either weak signal sources or trace amount of analyte(s). 
The two main methods of enhancing the signal are 
(1) the use of electronic hardware devices, such as filters, or equivalent computer software algorithms to process signals from the measurement as they pass through the instrument and 
(2) post measurement mathematical treatment of data. Among the more useful post measurement methods are the statistical techniques.
In addition to signal enhancement, these techniques aid in identifying sources of error and determining precision, while providing a method for an objective comparison of results. This module will deal with some common noise-reduction techniques and briefly review important statistical methods typically used in the treatment of instrumental data.
After watching this video lecture you will learn about:
· Signal to Noise Ratio
· Sensitivity and detection limit 
· Sources of Noise 
· Hardware techniques for Signal to Noise enhancement 
· Software techniques for Signal to Noise enhancement 
· Data treatment by filtering, Smoothing, and averaging

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